BioPharmNet
Topics
BioPharmNet forum
 
Navigation
This topic is managed by the Multiplicity Advisory Board (Alex Dmitrienko).
Multiplicity issues
This page includes links to articles on software implementation of multiple testing procedures in pre-clinical and clinical applications.
If you would like to contribute to the Code Depot project, the Multiplicity Advisory Board encourages you to post relevant information in this discussion thread in the BioPharmNet forum.
Multiplicity issues in clinical trials
Dmitrienko, A., Wiens, B.L., Tamhane, A.C., Wang, X. (2007). Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives. Statistics in Medicine. 26, 2465-2478 [SAS code and typographical errors].
Tree gatekeeping procedures serve as an extension of serial and parallel gatekeeping procedures and can be used in clinical trials with multi-dimensional objectives (multiple endpoints, doses, tests, etc) and clinical trials with logical restrictions.