The Mediana package is an R package which provides a framework for general simulation-based power and sample size calculations. This package utilizes the Clinical Scenario Evaluation (CSE) framework.

Expert and development teams

Package design: Alex Dmitrienko (Mediana Inc).

Core development team: Gautier Paux (Servier), Alex Dmitrienko (Mediana Inc).

Extended development team: Thomas Brechenmacher (QuintilesIMS), Fei Chen (Johnson and Johnson), Ilya Lipkovich (QuintilesIMS), Ming-Dauh Wang (Lilly).

Expert team: Keaven Anderson (Merck), Frank Harrell (Vanderbilt University), Mani Lakshminarayanan (Pfizer), Brian Millen (Lilly), Jose Pinheiro (Johnson and Johnson), Thomas Schmelter (Bayer).


The latest stable version of the Mediana package (Version 1.0.1) was released on July 26, 2015 and can be installed from the CRAN web site:

The latest development version of the Mediana package can be installed from the GitHiub web site:

Online manual

The package’s online manual is available at: